Recombinant human MORF4L1 protein

MORF4L1 (mortality factor 4-like protein 1), also known as MRG15, belongs to the MRG family. This protein is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. MORF4L1 is a transcription factor expressed in a variety of human tissues, and its orthologs have been found in many other eukaryotes which constitute the MRG protein family. The C-terminal part of MRG15 forms a conserved MRG domain which is involved in interactions with the tumor suppressor protein retinoblastoma and a nucleoprotein. Recombinant human MORF4L1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

Mortality factor 4-like protein 1, Eaf3, FWP006, HsT17725, MEAF3, MORFRG15, MRG15, S863-6

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

39.8 kDa (347aa) confirmed by MALDI-TOF

Additionnal Information

MORF4L1, Mortality factor 4-like protein 1, Eaf3, FWP006, HsT17725, MEAF3, MORFRG15, MRG15, S863-6, ATGP1494-10 µg, ATGP1494-20 µg, ATGP1494-50 µg, ATGP1494-100 µg, ATGP1494-250 µg, ATGP1494-500 µg, ATGP1494-1 mg, ATGP1494-10, ATGP1494-20, ATGP1494-50, ATGP1494-100, ATGP1494-250, ATGP1494-500, ATGP1494-1

References & Citations

Pardo P.S., et al. (2002) J. Biol. Chem. 277:50860-50866; ; Zhang P., et al. (2006) Protein Sci. 15:2423-2434

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol, 0.15M NaCl, 1mM DTT

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_006782

Uniprot Accession Number

Q9UBU8

Species

Human

AA Sequence

MAPKQD PKPKFQEGER VLCFHGPLLY EAKCVKVAIK DKQVKYFIHY SGWNKNWDEW VPESRVLKYV DTNLQKQREL QKANQEQYAE GKMRGAAPGK KTSGLQQKNV EVKTKKNKQK TPGNGDGGST SETPQPPRKK RARVDPTVEN EETFMNRVEV KVKIPEELKP WLVDDWDLIT RQKQLFYLPA KKNVDSILED YANYKKSRGN TDNKEYAVNE VVAGIKEYFN VMLGTQLLYK FERPQYAEIL ADHPDAPMSQ VYGAPHLLRL FVRIGAMLAY TPLDEKSLAL LLNYLHDFLK YLAKNSATLF SASDYEVAPP EYHRKAV