Recombinant Influenza A H3N2 Hemagglutinin/HA1 protein
Influenza A virus H3N2 is a subtype of viruses that cause influenza (flu) . H3N2 viruses can infect birds and mammals. In birds, humans, and pigs, the virus has mutated into many strains. Hemagglutinin (HA) binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. It plays a major role in the determination of host range restriction and virulence and is responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Recombinant Influenza A virus (A/Perth/16/2009 H3N2) HA protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Hemagglutinin, Influenza A virus (A/Perth/16/2009 (H3N2) ) hemagglutinin, HA
Expression System
Baculovirus
Antigen Species
Human, Influenza A-H3N2 (human)
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
37.8 kDa (339aa)
Additionnal Information
References & Citations
Alymova IV., et al. (2011) J Virol. 85 (23) :12324-33.; ; Cappuccio JA., et al. (2011) J Gen Virol. 92 (12) :2871-8.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Other
NCBI Accession Number
ACS71642.1
Uniprot Accession Number
C6KNH7
Species
Human, Influenza A-H3N2 (human)
AA Sequence
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