Recombinant human CBX5 protein
Chromobox homolog 5, also known as CBX5, is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. CBX5 is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. It has a pseudogene located on chromosome 3. Also, The CBX5 proteins reassociate with chromatin at the end of mitosis, as Histone H3 is dephosphorylated. Recombinant human CBX5 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Chromobox homolog 5, HP1, HP1A
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
24.8 kDa (215aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Koike N., et al. (2000) FEBS Lett. 467:17-21.; ; Verreault A., et al. (1996) Cell. 87:95-104
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 0.1M NaCl
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_001120794
Uniprot Accession Number
P45973
Species
Human
AA Sequence
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