Recombinant human LSM3 protein
LSM3 (u6 small nuclear RNA Associated Sm-like protein) belongs to the snRNP Sm proteins family. Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. Recombinant human LSM3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
U6 snRNA-associated Sm-like protein, SMX4, uSS2, YLR438C
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
14.3 kDa (125aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Lehner, Ben, et al. (2004) Genome Res. (united States) 14 (7) : 1315-23.; ; Achsel T., et al. (1999) EMBO J. 18:5789-5802
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 100 mM NaCl
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_055278
Uniprot Accession Number
P62310
Species
Human
AA Sequence
MADDVDQ QQTTNTVEEP LDLIRLSLDE RIYVKMRNDR ELRGRLHAYD QHLNMILGDV EETVTTIEID EETYEEIYKS TKRNIPMLFV RGDGVVLVAP PLRVG
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