Recombinant human EXOSC5 protein
EXOSC5, also known as exosome component 5, belongs to the RNase PH family. EXOSC5 has been shown to interact with Exosome component 8 and Exosome component 1. It is Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. It highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis. Recombinant human EXOSC5 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Exosome complex component RRP46, hRrp46p, p12B, RRP41B, RRP46, Rrp46p
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
27.5 kDa (256aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Mukherjee D., et al. (2002) EMBO J. 21:165-174; ; Basu u., et al. (2011) Cell 144:353-363
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 2mM DTT, 30% glycerol, 200 mM NaCl
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_064543.3
Uniprot Accession Number
Q9NQT4
Species
Human
AA Sequence
Frequently Asked Questions
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