Recombinant human CBX3 protein
CBX3, also known as chromobox protein homolog 3, seems to be involved in transcriptional silencing in heterochromatin-like complexes. This protein recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. It involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Recombinant human CBX3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Chromobox protein homolog 3, HECH, HP1-GAMMA, HP1Hs-gamma
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
23.4 kDa (207aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Koike N., et al. (2000) FEBS Lett. 467:17-21; ; Lachner M., et al. (2001) Nature. 410:116-120;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_057671
Uniprot Accession Number
Q13185
Species
Human
AA Sequence
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