Recombinant human Livin beta protein
Livin isoform beta is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING zinc finger (RZF) domain. Livin isoform beta has direct interaction with several caspases including caspase-3, -7, and -9. This protein inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP. Recombinant human Livin beta protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Livin inhibitor of apoptosis isoform beta, BIRC7, KIAP, ML-IAP, MLIAP, RNF50
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
33.4 kDa (304aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Kasof GM., et al. (2001) . J Biol Chem. 276 (5) :3238-46. ; ; Ashhab Y., et al. (2001) . FEBS Lett. 495 (1-2) :56-60.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 40% glycerol, 300 mM NaCl, 1mM EDTA
Scientific Category
Apoptosis
NCBI Accession Number
NP_071444
Uniprot Accession Number
Q96CA5
Species
Human
AA Sequence
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