Recombinant human GMPR protein

GMPR, also known as guanosine monophosphate reductase, catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Recombinant human GMPR protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

Guanosine monophosphate reductase, GMPR1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

39.5 kDa (365aa) confirmed by MALDI-TOF

Additionnal Information

GMPR, Guanosine monophosphate reductase, GMPR1, ATGP1410-10 µg, ATGP1410-20 µg, ATGP1410-50 µg, ATGP1410-100 µg, ATGP1410-250 µg, ATGP1410-500 µg, ATGP1410-1 mg, ATGP1410-10, ATGP1410-20, ATGP1410-50, ATGP1410-100, ATGP1410-250, ATGP1410-500, ATGP1410-1

References & Citations

Yoshida A., et al. (1990) Cell. 62:11-12; ; Kanno H., et al. (1989) Cell. 58:595-606

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 40% glycerol, 0.15M NaCl, 1mM DTT

Scientific Category

Redox Proteins

NCBI Accession Number

AAH08281

Uniprot Accession Number

P36959

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MPRIDADLKL DFKDVLLRPK RSSLKSRAEV DLERTFTFRN SKQTYSGIPI IVANMDTVGT FEMAAVMSQH SMFTAIHKHY SLDDWKLFAT NHPECLQNVA VSSGSGQNDL EKMTSILEAV PQVKFICLDV ANGYSEHFVE FVKLVRAKFP EHTIMAGNVV TGEMVEELIL SGADIIKVGV GPGSVCTTRT KTGVGYPQLS AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM LGGMFSGHTE CAGEVIERNG RKLKLFYGMS SDTAMNKHAG GVAEYRASEG KTVEVPYKGD VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFS