Recombinant human Annexin A7/ANXA7 protein

ANXA7, also known as annexin A7, is a member of the annexin family of calcium-dependent phospholipid binding proteins. The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2. 0 and 2. 4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. Structural analysis of the protein suggests that Annexin A7 is a membrane binding protein with diverse properties including voltage sensitive calcium channel activity, ion selectivity and membrane fusion. Recombinant human ANXA7 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

Annexin A7, ANX7, SNX, SYNEXIN

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

52.9 kDa (490aa)

Additionnal Information

Annexin A7, ATGP1407-10 µg, ATGP1407-20 µg, ATGP1407-50 µg, ATGP1407-100 µg, ATGP1407-250 µg, ATGP1407-500 µg, ATGP1407-1 mg, ATGP1407-10, ATGP1407-20, ATGP1407-50, ATGP1407-100, ATGP1407-250, ATGP1407-500, ATGP1407-1

References & Citations

Shirvan A., et al. (1994) Biochemistry. 33:6888-6901; ; Shibata H., et al. (2008) J. Biol. Chem. 283:9623-9632

Other References

Sakamoto N et al., Anti-annexin A4 antibody as a biomarker for desquamative interstitial pneumonia. (J Autoimmun. 2025) {https://pubmed.ncbi.nlm.nih.gov/40156961/}

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM MES buffer (pH 5.0) containing 40% glycerol, 0.15M NaCl, 1mM DTT

Scientific Category

Cytoskeleton

NCBI Accession Number

NP_001147

Uniprot Accession Number

P20073

Species

Human

AA Sequence

MSYPGY PPTGYPPFPG YPPAGQESSF PPSGQYPYPS GFPPMGGGAY PQVPSSGYPG AGGYPAPGGY PAPGGYPGAP QPGGAPSYPG VPPGQGFGVP PGGAGFSGYP QPPSQSYGGG PAQVPLPGGF PGGQMPSQYP GGQPTYPSQP ATVTQVTQGT IRPAANFDAI RDAEILRKAM KGFGTDEQAI VDVVANRSND QRQKIKAAFK TSYGKDLIKD LKSELSGNME ELILALFMPP TYYDAWSLRK AMQGAGTQER VLIEILCTRT NQEIREIVRC YQSEFGRDLE KDIRSDTSGH FERLLVSMCQ GNRDENQSIN HQMAQEDAQR LYQAGEGRLG TDESCFNMIL ATRSFPQLRA TMEAYSRMAN RDLLSSVSRE FSGYVESGLK TILQCALNRP AFFAERLYYA MKGAGTDDST LVRIVVTRSE IDLVQIKQMF AQMYQKTLGT MIAGDTSGDY RRLLLAIVGQ