Recombinant human UNC119B protein
UCN119B (Protein unc-119 homolog B) belongs to the PDE6D/unc-119 family. This protein is enriched in the photoreceptors of the retina. It shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation gene. The mammalian multisubunit photoreceptor cGMP phosphodiesterase PDE alpha beta gamma 2 (PDE6 family) is a peripherally membrane-associated enzyme. Recombinant human uNC119B protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Protein unc-119 homolog B, POC7B, unc-119 lipid binding chaperone B, POC7 centriolar protein homolog B
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
30.3 kDa (271aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Li N, et al. (1998) Genomics. 49 (1) :76-82.; ; Ota T., et al. (2004) Nat. Genet. 36:40-45
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 100 mM NaCl
Scientific Category
Enzymes & Proteases
NCBI Accession Number
NP_001074002
Uniprot Accession Number
A6NIH7
Species
Human
AA Sequence
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