Recombinant human LRPAP protein

LRPAP1, also known as alpha-2-macroglobulin receptor-associated protein, belongs to the alpha-2-MRAP family. This protein interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. It is present on the cell surface forming a complex with the alpha 2 macroglobulin receptor heavy and light chains In complex with the alpha 2 MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis Recombinant human LRPAP1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

Alpha-2-macroglobulin receptor-associated protein, A2MRAP, A2RAP, HBP44, MGC138272, MRAP, RAP

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

40.4 kDa (348aa) confirmed by MALDI-TOF

Additionnal Information

LRPAP, alpha-2-macroglobulin receptor-associated protein, A2MRAP, A2RAP, HBP44, MGC138272, MRAP, RAP, ATGP1384-10 µg, ATGP1384-20 µg, ATGP1384-50 µg, ATGP1384-100 µg, ATGP1384-250 µg, ATGP1384-500 µg, ATGP1384-1 mg, ATGP1384-10, ATGP1384-20, ATGP1384-50, ATGP1384-100, ATGP1384-250, ATGP1384-500, ATGP1384-1

References & Citations

Vash B. et al. (1998) Blood 92: 3277-3285.; ; Trommsdorff M. et al. (1999) Cell 97: 689-701.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 1mM DTT

Scientific Category

Metabolism

NCBI Accession Number

NP_002328

Uniprot Accession Number

P30533

Species

Human

AA Sequence

YSREK NQPKPSPKRE SGEEFRMEKL NQLWEKAQRL HLPPVRLAEL HADLKIQERD ELAWKKLKLD GLDEDGEKEA RLIRNLNVIL AKYGLDGKKD ARQVTSNSLS GTQEDGLDDP RLEKLWHKAK TSGKFSGEEL DKLWREFLHH KEKVHEYNVL LETLSRTEEI HENVISPSDL SDIKGSVLHS RHTELKEKLR SINQGLDRLR RVSHQGYSTE AEFEEPRVID LWDLAQSANL TDKELEAFRE ELKHFEAKIE KHNHYQKQLE IAHEKLRHAE SVGDGERVSR SREKHALLEG RTKELGYTVK KHLQDLSGRI SRARHNEL