Recombinant human p18INK4c/CDKN2C protein
CDKN2C (Cyclin-dependent kinase 4 inhibitor C) belongs to the CDKN2 cyclin-dependent kinase inhibitor family. It has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. And this protein suppresses the cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Recombinant human CDKN2C protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Cyclin-dependent kinase 4 inhibitor C, INK4C, p18, p18-INK4C
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
20.7 kDa (192aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Blais A, et al. (1998) .) Biochem Biophys Res Commun 247 (1) : 146-53.; ; Serrano M, et al. (1994) . Nature 366 (6456) : 704-7.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% glycerol, 200 mM NaCl
Scientific Category
Cancer
NCBI Accession Number
NP_001253
Uniprot Accession Number
P42773
Species
Human
AA Sequence
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