Recombinant human TSSC4 protein

TSSC4 (tumor suppressing subtransferable candidate 4), also known as tumor suppressing STF cDNA 4 protein, belongs to the TSSC4 family. This protein is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15. 5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. It plays a role in malignancies and disease that involve this region as well as hematopoietic cell function This protein was widely expressed in nearly all adult tissues, TSSC4 is also found in fetal liver, lung, kidney and brain. Recombinant human TSSC4 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Tumor suppressing subtransferable candidate 4, Tumor suppressing subtransferable candidate 4, tumor suppressing STF cDNA 4

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

36.8 kDa (353aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Additionnal Information

TSSC4, Tumor suppressing subtransferable candidate 4, Tumor suppressing subtransferable candidate 4, tumor suppressing STF cDNA 4, ATGP1370-10 µg, ATGP1370-20 µg, ATGP1370-50 µg, ATGP1370-100 µg, ATGP1370-250 µg, ATGP1370-500 µg, ATGP1370-1 mg, ATGP1370-10, ATGP1370-20, ATGP1370-50, ATGP1370-100, ATGP1370-250, ATGP1370-500, ATGP1370-1

References & Citations

Lee M.P., et al. (1999) Hum. Mol. Genet. 8:683-690; ; Hu, R.J., et al. (1997) Genomics 46: 9-17.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2mM DTT,20% glycerol, 200 mM NaCl

Scientific Category

Cancer

NCBI Accession Number

AAH06091

Uniprot Accession Number

Q9Y5U2

Species

Human

AA Sequence

MAEAGT GEPSPSVEGE HGTEYDTLPS DTVSLSDSDS DLSLPGGAEV EALSPMGLPG EEDSGPDEPP SPPSGLLPAT VQPFHLRGMS STFSQRSRDI FDCLEGAARR APSSVAHTSM SDNGGFKRPL APSGRSPVEG LGRAHRSPAS PRVPPVPDYV AHPERWTKYS LEDVTEVSEQ SNQATALAFL GSQSLAAPTD CVSSFNQDPS SCGEGRVIFT KPVRGVEARH ERKRVLGKVG EPGRGGLGNP ATDRGEGPVE LAHLAGPGSP EAEEWGSPHG GLQEVEALSG SVHSGSVPGL PPVETVGFHG SRKRSRDHFR NKSSSPEDPG AEV