Recombinant human VSTM2L protein
VSTM2L, also known as V-set and transmembrane domain containing 2, is a new modulator of HN neuroprotective activity. It colocalizes with HN in distinct brain areas as well as in primary cultured neurons, where it plays a role in the modulation of neuronal viability. When tested in HN neuroprotection bioassays, it acts as a strong antagonist of HN neuroprotective activity. This protein is the first example of a secreted antagonist of HN and may play a role in the modulation of HN biological functions. Recombinant human VSTM2L protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
V-set and transmembrane domain containing 2 like, dJ1118M15.2, C20orf102, V set and transmembrane domain containing 2 like
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
22.6 kDa (205aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Collins S. et al. (2001) J. Clin. Neurosci. 8:387-397.; ; Rossini L. et al. (2011) FASEB J. 25:1983-2000
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl,1mM DTT, 0.1mM PMSF
Scientific Category
Other
NCBI Accession Number
AAH33818
Uniprot Accession Number
Q96N03
Species
Human
AA Sequence
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