Recombinant human VSTM2L protein

VSTM2L, also known as V-set and transmembrane domain containing 2, is a new modulator of HN neuroprotective activity. It colocalizes with HN in distinct brain areas as well as in primary cultured neurons, where it plays a role in the modulation of neuronal viability. When tested in HN neuroprotection bioassays, it acts as a strong antagonist of HN neuroprotective activity. This protein is the first example of a secreted antagonist of HN and may play a role in the modulation of HN biological functions. Recombinant human VSTM2L protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

V-set and transmembrane domain containing 2 like, dJ1118M15.2, C20orf102, V set and transmembrane domain containing 2 like

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

22.6 kDa (205aa) confirmed by MALDI-TOF

Additionnal Information

VSTM2L, V-set and transmembrane domain containing 2 like, dJ1118M15.2, C20orf102, V set and transmembrane domain containing 2 like, ATGP1364-10 µg, ATGP1364-20 µg, ATGP1364-50 µg, ATGP1364-100 µg, ATGP1364-250 µg, ATGP1364-500 µg, ATGP1364-1 mg, ATGP1364-10, ATGP1364-20, ATGP1364-50, ATGP1364-100, ATGP1364-250, ATGP1364-500, ATGP1364-1

References & Citations

Collins S. et al. (2001) J. Clin. Neurosci. 8:387-397.; ; Rossini L. et al. (2011) FASEB J. 25:1983-2000

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl,1mM DTT, 0.1mM PMSF

Scientific Category

Other

NCBI Accession Number

AAH33818

Uniprot Accession Number

Q96N03

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMTRPAG HAPWDNHVSG HALFTETPHD MTARTGEDVE MACSFRGSGS PSYSLEIQWW YVRSHRDWTD KQAWASNQLK ASQQEDAGKE ATKISVVKVV GSNISHKLRL SRVKPTDEGS YECRVIDFSD GKARHHKVKA YLRVQPGENS VLHLPEAPPA APAPPPPKPG KELRKRSVDQ EACSL