Recombinant human Cystatin SN protein
CST1 (Cystatin-SN) is a member of the type 2 salivary cystatin family found in a variety of fluids and secretions, including plasma, tears, and saliva. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. CST1 was upregulated in cancerous lesions of gastric cancer tissues compared to noncancerous regions and clinicopathological analysis showed a significant correlation between high expression of CST1. Recombinant human CST1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Cystatin SN, Cystain-SA-I, Cystatin-1, Cystatin-SN, Salivary cystatin-SA-1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
16.9 kDa (145aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Choi EH, et al. (2009) Clin Chim Acta. 406 (1-2) :45-51.; ; Ryan C.M., et al. (2010) J. Am. Soc. Mass Spectrom. 21:908-917
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% glycerol, 100 mM NaCl
Scientific Category
Protease inhibitors
NCBI Accession Number
NP_001889
Uniprot Accession Number
P01037
Species
Human
AA Sequence
WSPKEE DRIIPGGIYN ADLNDEWVQR ALHFAISEYN KATKDDYYRR PLRVLRARQQ TVGGVNYFFD VEVGRTICTK SQPNLDTCAF HEQPELQKKQ LCSFEIYEVP WENRRSLVKS RCQES
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