Recombinant human Histone Deacetylase 8/HDAC8 protein
HDAC8, also known as histone deacetylase 8, belongs to class 1 of the histone deacetylase/acuc/apha family. This protein is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Recombinant human HDAC8 protein, fused to His-tag at C-terminus, was expressed in Sf9 insect cell and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Protein deacetylase HDAC8, Protein decrotonylase HDAC8, Wilson-Turner X-linked mental retardation syndrome HDACL1, CDA07, WTS, MRXS6, RPD3, KDAC8
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Endotoxin
<1 EU per 1ug of protein (determined by LAL method)
Purity
> 80% by SDS-PAGE
Molecular Weight
42.6 kDa (383aa)
Additionnal Information
References & Citations
Hu E., et al. (2000) J. Biol. Chem. 275:15254-15264; ; Buggy J.J., et al. (2000) Biochem. J. 350:199-205
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_060956
Uniprot Accession Number
Q9BY41
Species
Human
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