Recombinant human SNRPC protein
SNRPC belongs to the u1 small nuclear ribonucleoprotein C family. This protein component of the u1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. This protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. Recombinant human SNRPC protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
U1 small nuclear ribonucleoprotein C, u1C, Yhc1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
19.8 kDa (182aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
References & Citations
Sillekens P.T.G., et al. (1988) Nucleic Acids Res. 16:8307-8321; ; Muto Y., et al. (2004) J. Mol. Biol. 341:185-198
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 50% glycerol, 0.3M NaCl, 5mM DTT, 2mM EDTA
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_003084.1
Uniprot Accession Number
P09234
Species
Human
AA Sequence
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