Recombinant human HDHD2B/LHPP protein
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase, also known as LHPP, is a member of the HAD-like hydrolase superfamily. It is a unique enzyme that hydrolyzes not only oxygen-phosphorus bonds in inorganic pyrophosphate but also nitrogen-phosphorus bonds in phospholysine, phosphohistidine and imidodiphosphate in vitro. LHPP is expressed in liver, kidney and moderately in brain. Recombinant human LHPP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase, HDHD2B
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
33.5 kDa (307aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Neff C D., et al. (2009) Mol Psychiatry. 14:621-630.; ; Chen L., et al. (2005) Front Biosci. 10:1961-1976.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl, 0.1mM PMSF
Scientific Category
Enzymes & Proteases
NCBI Accession Number
NP_071409.3
Uniprot Accession Number
Q9H008
Species
Human
AA Sequence
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