Recombinant human Importin beta/KPNB1 protein
NTF97, also known as KPNB1, is a member of the importin beta family. This protein is involved in nuclear protein import, either by associating itself with an adapter protein (for example, importin-alpha subunit which binds to nuclear localization signals (NLS) in cargo substrates), or by acting autonomously as a nuclear transport receptor (serves as NLS receptor, docking of the importin/substrate complex to the nuclear pore complex) Recombinant human KPNB1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Importin subunit beta-1, IMB1, Impnb, IPO1, IPOB, NTF97
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
99.6 kDa (899aa)
Additionnal Information
References & Citations
Moroianu J., et al. (1995) Proc Natl Acad Sci. 92:2008-2011.; ; Moroianu J., et al. (1996) Proc Natl Acad Sci. 93:6572-6576.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 0.1M NaCl
Scientific Category
Signal Transduction
NCBI Accession Number
NP_002256.2
Uniprot Accession Number
Q14974
Species
Human
AA Sequence
Frequently Asked Questions
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