Recombinant human MRGBP protein
MRG-binding protein, also known as MRGBP, is a 204 amino acid protein which is a part of the NuA4 histone acetyltransferase (HAT) complex that acts to acetylate histone H2A and H4. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. MRGBP has potential to interact with MORF4L1/MRG15 and MORF4L2/MRGX. Recombinant human MRGBP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
MRG-binding protein, MRG15BP, uRCC4, C20orf20
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
24.5 kDa (224aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
References & Citations
Doyon Y., et al. (2004) Mol Cell Biol. 24:1884-1896.; ; Squatrito M., et al. (2006) Trends Cell Biol. 16:433-442.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 0.2M NaCl
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_060740
Uniprot Accession Number
Q9NV56
Species
Human
AA Sequence
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