Recombinant human MRGBP protein

MRG-binding protein, also known as MRGBP, is a 204 amino acid protein which is a part of the NuA4 histone acetyltransferase (HAT) complex that acts to acetylate histone H2A and H4. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. MRGBP has potential to interact with MORF4L1/MRG15 and MORF4L2/MRGX. Recombinant human MRGBP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

MRG-binding protein, MRG15BP, uRCC4, C20orf20

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

24.5 kDa (224aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Additionnal Information

MRGBP, MRG-binding protein, MRG15BP, uRCC4, C20orf20, ATGP1315-10 µg, ATGP1315-20 µg, ATGP1315-50 µg, ATGP1315-100 µg, ATGP1315-250 µg, ATGP1315-500 µg, ATGP1315-1 mg, ATGP1315-10, ATGP1315-20, ATGP1315-50, ATGP1315-100, ATGP1315-250, ATGP1315-500, ATGP1315-1

References & Citations

Doyon Y., et al. (2004) Mol Cell Biol. 24:1884-1896.; ; Squatrito M., et al. (2006) Trends Cell Biol. 16:433-442.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 0.2M NaCl

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_060740

Uniprot Accession Number

Q9NV56

Species

Human

AA Sequence

MGEAEVGGGG AAGDKGPGEA ATSPAEETVV WSPEVEVCLF HAMLGHKPVG VNRHFHMICI RDKFSQNIGR QVPSKVIWDH LSTMYDMQAL HESEILPFPN PERNFVLPEE IIQEVREGKV MIEEEMKEEM KEDVDPHNGA DDVFSSSGSL GKASEKSSKD KEKNSSDLGC KEGADKRKRS RVTDKVLTAN SNPSSPSAAK RRRT

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