Recombinant human RCAN2 protein

Calcipressin-2, also known as RCAN2, belonging to the RCAN (Regulator of calcineurin) family modulate the activity of Calcineurin through a valine-rich region within their carboxyl tail. RCANs compete with NFAT (nuclear factor of activated T-cells) for binding to the same docking site in calcineurin, which results in either inhibition or activation of calcineurin activity. RCAN2 is a Ca (2+) dependent protein phosphatase that is involed in several neuornal functions. Recombinant human RCAN2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Calcipressin-2, CSP2, DSCR1L1, hRCN2, MCIP2, RCN2, ZAKI-4, ZAKI4

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

24.1 kDa (217aa) confirmed by MALDI-TOF

Additionnal Information

RCAN2, Calcipressin-2, CSP2, DSCR1L1, hRCN2, MCIP2, RCN2, ZAKI-4, ZAKI4, ATGP1309-10 µg, ATGP1309-20 µg, ATGP1309-50 µg, ATGP1309-100 µg, ATGP1309-250 µg, ATGP1309-500 µg, ATGP1309-1 mg, ATGP1309-10, ATGP1309-20, ATGP1309-50, ATGP1309-100, ATGP1309-250, ATGP1309-500, ATGP1309-1

References & Citations

Qin L., et al. (2006) Mal Cancer Res. 4:811-820.; ; Porta S., et al. (2007) Eur J Neurosci. 26:1213-1226.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 0.2M NaCl

Scientific Category

Signal Transduction

NCBI Accession Number

NP_005813

Uniprot Accession Number

Q14206

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD DCVTFQLFKS FRRVRINFSN PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPSSPPVG WQPINDATPV LNYDLLYAVA KLGPGEKYEL HAGTESTPSV VVHVCDSDIE EEEDPKTSPK PKIIQTRRPG LPPSVSN