Recombinant human DUSP23 protein
DuSP23, also known as low molecular mass dual specificity phosphatase 3 (LDP-3), belongs to the protein-tyrosine phosphatase family. This protein is a protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. This protein able to enhance activation of JNK and p38 (MAPK14) . Recombinant human DuSP23 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Dual specificity protein phosphatase 23, DuSP25, LDP-3, MOSP, VHZ, Low molecular mass dual specificity phosphatase 3, VH1-like phosphatase Z
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
18.8 kDa (170aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Alonso A., et al. (2004) J. Biol. Chem. 279:35768-35774; ; Wu Q, et al. (2004) Int J Biochem Cell Biol. 36 (8) :1542-53.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% glycerol, 100 mM NaCl
Scientific Category
Cell Cycle
NCBI Accession Number
NP_060293
Uniprot Accession Number
Q9BVJ7
Species
Human
AA Sequence
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