Recombinant human RAB23 protein
RAB23, also known as ras-related protein Rab23, is a member of the Rab family of proteins and localizes to the cytoplasmic side of the cell membrane. This protein is thought to to play a role in intracellular protein transportation and signal transduction mediated by small GTPases. RAB23 is an essential negative regulator of the Sonic hedgehog signaling pathway. Mutations in the gene encoding RAB23 may result in Carpenter syndrome a condition characterized by obesity, cardiac defects, polysyndactyly and craniosynostosis. Recombinant human RAB23 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Ras-related protein Rab-23, DKFZp781H0695, HSPC137, MGC8900, RAB23 member RAS oncogene family
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
28.5 kDa (254aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Marcos I. et al. (2003) Int J Mol Med. 12:983-987.; ; Eggenschwiler JT. et al. (2001) Nature. 412:194-198.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol, 1mM DTT, 0.1mM PMSF
Scientific Category
Signal Transduction
NCBI Accession Number
NP_057361
Uniprot Accession Number
Q9ULC3
Species
Human
AA Sequence
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