Recombinant human PA28 beta/PSME2 protein
PSME2, also known as proteasome (prosome, macropain) activator subunit 2, is an IFN-gamma inducible proteasome activator required for presentation of certain major histocompatibility (MHC) class I antigens. Downregulation of PSME2 results in abnormal proteasome activation and has been implicated in the development of intimal hyperplasia (IH) in animal models. Recombinant human PSME2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
29.5 kDa (259aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Kohda K. et al. (1998) J. Immunol. 160: 4923-4935.; ; Fabunmi R.P. et al. (2001) J. Cell. Sci. 114: 29-36
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl,1mM DTT, 0.1mM PMSF
Scientific Category
Ubiquitination
NCBI Accession Number
AAH72025.1
Uniprot Accession Number
Q9UL46
Species
Human
AA Sequence
Frequently Asked Questions
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