Recombinant human NACA protein
NACA is member of the nascent polypeptide associated complex (NAC) alpha subunit family that participate in preventing inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER) . Most NACA proteins localize to both nucleus as well as cytoplasm, and contain NAC-A/B (NAC-alpha/beta) and uBA (ubiquitin-associated) domains. The uBA domain is associated with proteins involved in the ubiquitin-proteasome pathway for protein degradation. Recombinant human NACA protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Nascent polypeptide-associated complex alpha subunit, HSD48, MGC117224, NACA1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Purity
> 95% by SDS-PAGE
Molecular Weight
25.5 kDa (235aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Additionnal Information
References & Citations
Lopez S., et al. (2005) J Cell Sci. 118 (8) :1595-605.; ; Stilo R., et al. (2003) Biochem Biophys Res Commun. 303 (4) :1034-41.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.15M NaCl
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_001106672.1
Uniprot Accession Number
Q13765
Species
Human
AA Sequence
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