Recombinant human GADD45GIP1 protein
GADD45GIP1, also known as CRIF1, is a nuclear protein that plays a role in apoptosis control. This protein is expressed in a variety of tissues, including heart, thyroid, trachea, kidney, ovary, pancreas, testis and stomach. It functions as a negative regulator of G1 to S phase cell cycle production, specifically by working with GADD45 proteins to inhibit the activity of cyclin-dependent kinases. Recombinant human GADD45GIP1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Growth arrest and DNA damage-inducible proteins-interacting protein 1, CKBBP2, CRIF1, MGC4667, MGC4758, PLINP-1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
22.6 kDa (196aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Chung HK., et al. (2003) J Biol Chem. 278 (30) :28079-88.; ; Park KC., et al. (2005) Mol Endocrinol. 19 (1) :12-24.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 40% glycerol, 2mM DTT, 0.2M NaCl.
Scientific Category
Cancer
NCBI Accession Number
NP_443082
Uniprot Accession Number
Q8TAE8
Species
Human
AA Sequence
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