Recombinant human COPS8 protein

COP9 signalosome complex subunit 8 isoform 1, also known as COPS8, is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Recombinant human COPS8 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

COP9 signalosome complex subunit 8, COP9, CSN8, SGN8

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

25.3 kDa (229aa)

Additionnal Information

COPS8, COP9 signalosome complex subunit 8, COP9, CSN8, SGN8, ATGP1276-10 µg, ATGP1276-20 µg, ATGP1276-50 µg, ATGP1276-100 µg, ATGP1276-250 µg, ATGP1276-500 µg, ATGP1276-1 mg, ATGP1276-10, ATGP1276-20, ATGP1276-50, ATGP1276-100, ATGP1276-250, ATGP1276-500, ATGP1276-1

References & Citations

Lyapina S., et al. (2001) Science. 292:1382-5.; ; Bech Otschir D., et al. (2001) EMBO J. 20:1630-9.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Ubiquitination

NCBI Accession Number

NP_006701

Uniprot Accession Number

Q99627

Species

Human

AA Sequence

MPVAVMAESA FSFKKLLDQC ENQELEAPGG IATPPVYGQL LALYLLHNDM NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGILE QGWQADSTTR MVLPRKPVAG ALDVSFNKFI PLSEPAPVPP IPNEQQLARL TDYVAFLEN