Recombinant human COPS8 protein
COP9 signalosome complex subunit 8 isoform 1, also known as COPS8, is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Recombinant human COPS8 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
COP9 signalosome complex subunit 8, COP9, CSN8, SGN8
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
25.3 kDa (229aa)
Additionnal Information
References & Citations
Lyapina S., et al. (2001) Science. 292:1382-5.; ; Bech Otschir D., et al. (2001) EMBO J. 20:1630-9.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Ubiquitination
NCBI Accession Number
NP_006701
Uniprot Accession Number
Q99627
Species
Human
AA Sequence
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