Recombinant human TNNC1 protein
Troponin C type 1, also known as TNNC1, is a member of troponins family. Troponin has 3 subunits, Troponin I (Tn-I), Troponin T (Tn-T) and Troponin C (Tn-C) . Tn-I subunit inhibits actomyosin ATPase and Tn-T subunit binds tropomyosin and Tn-C, while Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. TNNC1 is dumbbell-shaped and has a hydrophobic pocket that increases the contractile force of muscle fibers. Recombinant human TNNC1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Troponin C type 1, CMD1Z, CMH13, TN-C, TNC, TNNC
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
20.5 kDa (181aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Wu A H) ., et al. (1998) Clin Chem. 44:1198-1208.; ; Hamm C W., et al. (2001) Thromb Res. 103:S63-S69.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl
Scientific Category
Cytoskeleton
NCBI Accession Number
NP_003271
Uniprot Accession Number
P63316
Species
Human
AA Sequence
Frequently Asked Questions
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