Recombinant human FAM3C protein

FAB3C belongs to the FAM3 family and contains a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. Fam3c may be a downstream target gene for the Nkx5. 1 transcription factor, and may thus be involved in cell differentiation and proliferation during inner ear embryogenesis. Also, it may be involved in retinal laminar formation and promotes epithelial to mesenchymal transition. Recombinant human FAM3C, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Protein FAM3C, ILEI, FAM3 metabolism regulating signaling molecule C, family with sequence similarity 3 member C, GS3876, predicted osteoblast protein, interleukin-like EMT inducer, interleukin-like epithelial-mesenchymal transition inducer

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

24.5kD (224aa) confirmed by MALDI-TOF

Additionnal Information

FAM3C, Protein FAM3C, ILEI, ATGP1251-10 µg, ATGP1251-20 µg, ATGP1251-50 µg, ATGP1251-100 µg, ATGP1251-250 µg, ATGP1251-500 µg, ATGP1251-1 mg, ATGP1251-10, ATGP1251-20, ATGP1251-50, ATGP1251-100, ATGP1251-250, ATGP1251-500, ATGP1251-1

References & Citations

Zhu Y, et al. (2002) Genomics 80 (2) : 144-50.; ; Pilipenko VV, et al. (2004) Gene. 335:159-68.

Other References

Nakano M, et al. Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations. (J Alzheimers Dis. 2021) {https://pubmed.ncbi.nlm.nih.gov/33492290/}

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 20% glycerol, 200 mM NaCl

Scientific Category

Immunology

NCBI Accession Number

NP_055703

Uniprot Accession Number

Q92520

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MQVFEIKMDA SLGNLFARSA LDTAARSTKP PRYKCGISKA CPEKHFAFKM ASGAANVVGP KICLEDNVLM SGVKNNVGRG INVALANGKT GEVLDTKYFD MWGGDVAPFI EFLKAIQDGT IVLMGTYDDG ATKLNDEARR LIADLGSTSI TNLGFRDNWV FCGGKGIKTK SPFEQHIKNN KDTNKYEGWP EVVEMEGCIP QKQD