Recombinant human RAB24 protein

RAB24 belongs to the small GTPase superfamily. Members of the Rab GTPase family regulate intracellular protein trafficking, but the specific function of RAB24 remains unknown. RAB24 is distributed in the endoplasmic reticulum/cis-Golgi region and on late endosomal structures, and this subcellular distribution pattern of RAB24 may indicate its involvement in autophagy-related processes. RAB24 presents unusual characteristics, including low intrinsic GTPase activity, and is inefficiently prenylated when compared with other Rab proteins. Also suggested that RAB24 might play a unique role in the degradation of misfolded cellular proteins or trafficking of proteins to the nuclear envelope. Recombinant human RAB24 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.