Recombinant human RAB24 protein
RAB24 belongs to the small GTPase superfamily. Members of the Rab GTPase family regulate intracellular protein trafficking, but the specific function of RAB24 remains unknown. RAB24 is distributed in the endoplasmic reticulum/cis-Golgi region and on late endosomal structures, and this subcellular distribution pattern of RAB24 may indicate its involvement in autophagy-related processes. RAB24 presents unusual characteristics, including low intrinsic GTPase activity, and is inefficiently prenylated when compared with other Rab proteins. Also suggested that RAB24 might play a unique role in the degradation of misfolded cellular proteins or trafficking of proteins to the nuclear envelope. Recombinant human RAB24 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Ras-related protein Rab-24, RAB24 member RAS oncogene family
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
25.6 kDa (227aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Maltese WA, et al. (2002) BMC Cell Biol. 3:25.; ; Wu M, Yin G, et al. (2006) Int J Mol Med. 17 (5) :749-54.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 30% glycerol, 100 mM NaCl, 1mM EDTA
Scientific Category
Signal Transduction
NCBI Accession Number
NP_570137
Uniprot Accession Number
Q969Q5
Species
Human
AA Sequence
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