Recombinant human SEPT6/SEPTIN6 protein

Septins belong to the GTPase superclass of proteins and have been functionally implicated in cytokinesis and the maintenance of cellular morphology. SEPT6 is member of septin family and interact with SEPT2. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. Recombinant human SEPT6 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Septin 6, 40788

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

52.1 kDa, (457aa)

Additionnal Information

SEPT 6, SEPT-6, Septin-6, Septin 6, 40788, ATGP1244-10 µg, ATGP1244-20 µg, ATGP1244-50 µg, ATGP1244-100 µg, ATGP1244-250 µg, ATGP1244-500 µg, ATGP1244-1 mg, ATGP1244-010, ATGP1244-020, ATGP1244-050, ATGP1244-100, ATGP1244-250, ATGP1244-500, ATGP1244-01M

References & Citations

Nakahira M, et al. (2010) PLoS One. 5 (11) :e13799; ; Kremer B.E., et al. (2007) Cell 130:837-850

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% glycerol, 100 mM NaCl

Scientific Category

Cell Cycle

NCBI Accession Number

AAH09291

Uniprot Accession Number

Q14141

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMAATDIA RQVGEGCRTV PLAGHVGFDS LPDQLVNKSV SQGFCFNILC VGETGLGKST LMDTLFNTKF EGEPATHTQP GVQLQSNTYD LQESNVRLKL TIVSTVGFGD QINKEDSYKP IVEFIDAQFE AYLQEELKIR RVLHTYHDSR IHVCLYFIAP TGHSLKSLDL VTMKKLDSKV NIIPIIAKAD AISKSELTKF KIKITSELVS NGVQIYQFPT DDESVAEING TMNAHLPFAV IGSTEELKIG NKMMRARQYP WGTVQVENEA HCDFVKLREM LIRVNMEDLR EQTHTRHYEL YRRCKLEEMG FKDTDPDSKP FSLQETYEAK RNEFLGELQK KEEEMRQMFV QRVKEKEAEL KEAEKELHEK FDRLKKLHQD EKKKLEDKKK SLDDEVNAFK QRKTAAELPQ SQGSQAGGSQ TLKRDKEKKN NPWLCTE