Recombinant human C8G protein
C8gamma, also known as C8G, is one of three polypeptides (along with C8 alpha and C8 beta) that constitutes C8, a component of the complement system. C8 participates in the formation of Membrane Attack Complex (MAC) . Patients with deficiency in C8 are vulnerable to certain bacteria infection. C8gamma is a secreted protein that is able to bind retinol and belongs to the lipocalin family and calycin superfamily. It is synthesised in the liver, monocytes and fibroblast and functions to clear pathogens from an infected host. Recombinant human C8G protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Complement component 8 gamma polypeptide, complement component 8, gamma polypeptide, C8C
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
22.6 kDa (203aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Chiswell B., et al. (2007) Biochim Biophys Acta. 1774 (5) :637-44.; ; Schreck SF., et al. (2000) Biochim Biophys Acta. 1482 (1-2) :199-208.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.15M NaCl.
Scientific Category
Immunology
NCBI Accession Number
AAI13625
Uniprot Accession Number
P07360
Species
Human
AA Sequence
Frequently Asked Questions
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