Recombinant human ARFL3/ARL3 protein
ARL3, also known as ARFL3, is a member of the ARF-like protein (ARL) subfamily of small GTPases. unlike ARFs, ARL3 does not activate the cholera toxin ADP-ribosyltranferase. This protein is ubiquitously expressed. It may play a role in maintaining rod photoreceptor cells and regulating microtubule-dependent processes. Knockdown of ARL3 leads to altered cell morphology, failure of cytokinesis, acetylation of alpha tubulin and an increase in binucleated cells. Recombinant human ARL3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
ADP-ribosylation factor-like protein 3, ARFL3, ADP ribosylation factor like GTPase 3
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
23.0 kDa (206aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Bartolini F. et al. (2002) J Biol Chem. 277:14629-14634.; ; Hillig R.C. et al. (2001) Structure. 8:1239-1245.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol, 0.1M NaCl,1mM DTT, 0.1mM PMSF
Scientific Category
Cancer
NCBI Accession Number
NP_004302
Uniprot Accession Number
P36405
Species
Human
AA Sequence
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