Recombinant human DENR protein

DENR may be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. This protein plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1. Recombinant human DENR protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Density-regulated protein, DRP, DRP1, SMAP-3

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

24.2 kDa (218aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Additionnal Information

DENR, Density-regulated protein, DRP, DRP1, SMAP-3, ATGP1204-10 µg, ATGP1204-20 µg, ATGP1204-50 µg, ATGP1204-100 µg, ATGP1204-250 µg, ATGP1204-500 µg, ATGP1204-1 mg, ATGP1204-10, ATGP1204-20, ATGP1204-50, ATGP1204-100, ATGP1204-250, ATGP1204-500, ATGP1204-1

References & Citations

Deyo JE., et al. (1998) DNA Cell Biol. 17 (5) :437-47.; ; Oh JJ., et al. (1999) Nucleic Acids Res. 27 (20) :4008-17.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 2mM DTT, 0.15M NaCl.

Scientific Category

Signal Transduction

NCBI Accession Number

NP_003668

Uniprot Accession Number

O43583

Species

Human

AA Sequence

MAADISESSG ADCKGDPRNS AKLDADYPLR VLYCGVCSLP TEYCEYMPDV AKCRQWLEKN FPNEFAKLTV ENSPKQEAGI SEGQGTAGEE EEKKKQKRGG RGQIKQKKKT VPQKVTIAKI PRAKKKYVTR VCGLATFEID LKEAQRFFAQ KFSCGASVTG EDEIIIQGDF TDDIIDVIQE KWPEVDDDSI EDLGEVKK