Recombinant human MPI protein
Mannose-6-phosphate isomerase, also known as MPI, belongs to the mannose-6-phosphate isomerase type 1 family, and is expressed in all tissues, more abundantly in heart, brain and skeletal muscle. Localized to the cytoplasm, MPI utilizes zinc as a cofactor and catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib.
Product Specifications
Product Name Alternative
Mannose-6-phosphate isomerase, PMI, PMI1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
41.9 kDa (382aa)
Additionnal Information
References & Citations
Schollen E., et al. (2000) Hum Mutat. 16:247-252.; ; Proudfoot A E., et al. (1996) Biochem J. 318:437-442.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 5% glycerol
Scientific Category
Metabolism
NCBI Accession Number
AAH17351
Uniprot Accession Number
P34949
Species
Human
AA Sequence
Frequently Asked Questions
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