Recombinant human RGN protein
RGN (Regucalcin) belongs to the SMP-30/CGR1 family. This protein is Ca (2+) -binding protein that does not contain EF-hand motif of Ca (2+) -binding domain. RGN plays a pivotal role in the keep of intracellular Ca2+ homeostasis due to activating Ca2+ pump enzymes in the plasma membrane (basolateral membrane), microsomes (endoplasmic reticulum) and mitochondria of many cells. Also, it plays a multifunctional role in the regulation of cell functions in liver, kidney cortex, heart and brain and a suppressor protein for cell signaling systems in many cell types.
Product Specifications
Product Name Alternative
Regucalcin, RC, SMP30
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
35.4 kDa (319aa)
Additionnal Information
References & Citations
Chakraborti S., et al. (2010) Biochemistry. 49:3436-3444; ; Yamaguchi M., et al. (2005) Int J Mol Med. 15: 372-389
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2M urea, 20% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_690608
Uniprot Accession Number
Q15493
Species
Human
AA Sequence
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