Recombinant human Cofilin 2/CFL2 protein
CFL2 protein belongs to the actin-binding proteins ADF family that contains 1 ADF-H domain. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. Defects in CFL2 are the cause of nemaline myopathy type 7 (NEM7) . Recombinant human CFL2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
CFL2, Cofilin 2, NEM7
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
20.9 kDa (186a) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Agrawal P.B., et al. (2007) Am. J. Hum. Genet. 80:162-167; ; Gillett GT, et al. (1996) . Ann. Hum. Genet. 60 (Pt 3) : 201-11
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% glycerol, 50 mM Nacl
Scientific Category
Cytoskeleton
NCBI Accession Number
NP_068733
Uniprot Accession Number
Q9Y281
Species
Human
AA Sequence
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