Recombinant human KAT2A/GCN5 protein
GCN5L2 (General control of amino acid synthesis protein 5 like 2) belongs to the GCN5 family. It functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. GCN5L2 has been shown to interact with Ku70, TAF9, transcription initiation protein SPT3 homolog, TADA2L, Ku80 and DDB1. Recombinant human GCN5L2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
51.1 kDa (447a) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Guelman S., et al. (2009) Mol. Cell. Biol. 29:1176-1188; ; Col E., et al. (2001) J. Biol. Chem. 276:28179-28184
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 40% glycerol, 200 mM NaCl, 1mM EDTA
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_066564.2
Uniprot Accession Number
Q92830
Species
Human
AA Sequence
Frequently Asked Questions
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