Recombinant human DCAF7 protein
DCAF7, also known as DDB1-and CuL4-associated factor, involved in craniofacial development. This protein acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. This protein associates with DIAPH1 and controls GLI1 transcriptional activity. This protein could be involved in normal and disease skin development. Recombinant human DCAF7 protein, fused to His-tag at N-terminus, was expressed in E. coli and denatured using detergent during conventional chromatography purification process.
Product Specifications
Product Name Alternative
DDB1-and CuL4-associated factor 7, AN11, HAN11, SWAN-1, WDR68
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
33.6 kDa (298aa)
Additionnal Information
References & Citations
Morita K., et al. (2006) J. Dermatol. Sci. 44:11-20; ; Jin J., et al. (2006) Mol. Cell. 23:709-721
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 1mM DTT
Scientific Category
Development
NCBI Accession Number
NP_005819
Uniprot Accession Number
P61962
Species
Human
AA Sequence
Frequently Asked Questions
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