Recombinant human NT-4 protein
NTF4, also known as neurotrophin 4, is a member of a family of neurotrophic factors neurotrophins that control survival and differentiation of mammalian neurons. This protein is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derivedneurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF4-deficient mice only show minor cellular deficits and develop normally to adulthood.
Product Specifications
Product Name Alternative
Neurotrophin-4, NT4, NT5, NTF5, NT-4/5
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
14.1 kDa (131aa)
Additionnal Information
References & Citations
Pasutto F., et al. (2009) Am. J. Hum. Genet. 85:447-456.; ; Liu Y., et al. (2010) Am. J. Hum. Genet. 86:498-499.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 20% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_006170
Uniprot Accession Number
P34130
Species
Human
AA Sequence
MGVSETAPAS RRGELAVCDA VSGWVTDRRT AVDLRGREVE VLGEVPAAGG SPLRQYFFET RCKADNAEEG GPGAGGGGCR GVDRRHWVSE CKAKQSYVRA LTADAQGRVG WRWIRIDTAC VCTLLSRTGR A
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