Recombinant human RGS5 protein
RGS5, also known as regulator of G-protein signaling 5, binds directly to activated G alpha subunits and act as GTPase-activating proteins (GAPs) to attenuate and/or modulate hormone and neurotransmitter receptor-initiated signaling by both G alpha-GTP and G beta gamma. Vascular endothelial cells express the RGS protein RGS5, where it correlates with capillary morphogenesis, thus rendering it a candidate gene involved in capillary growth, angiogenesis, and also potentially the pathophysiology of stroke. Recombinant human RGS5 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Regulator of G-protein signaling 5, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
23.5 kDa (205aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Hepler J.R. et al. (1999) Trends Pharmacol. Sci. 20: 376-382.; ; Wieland T. et al. (2003) Pharmacol. Ther. 97: 95-115.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl,1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_003608
Uniprot Accession Number
O15539
Species
Human
AA Sequence
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