Recombinant human DCNL2/DCUN1D2 protein
DCN1-like protein 2, also known as DCuN1D2, which contains one DCuN1 domain and 1 uBA-like domain, may play a role in the neddylation of cullins that regulate SCF-type ubiquitin ligase complexes. The gene encoding Dcun1D2 exists on human chromosome 13. Chromosome 13 houses key tumor suppressor genes, including BRCA2 and RB1, which are associated with breast cancer susceptibility and retinoblastoma, respectively. Recombinant human DCuN1D2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Defective in cullin neddylation 1 domain containing 2, DCUN1 domain-containing protein 2, DCN1-like protein 2, C13orf17, DCUN1L2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
32.3 kDa (279aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Hassler M., et al. (2007) Mol Cell. 28:371-385.; ; Dunham A., et al. (2004) Nature. 428:522-528.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 0.1M NaCl
Scientific Category
Ubiquitination
NCBI Accession Number
NP_001014305
Uniprot Accession Number
Q6PH85
Species
Human
AA Sequence
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