Recombinant human Histone Deacetylase 2/HDAC2 protein
HDAC2 belongs to the histone deacetylase family that act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones. It forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. It also plays an important role in transcriptional regulation, cell cycle progression and developmental events. Recombinant human HDAC2 protein was expressed with c-terminal His-tag in high-5 cells using baculovirus expression system and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Histone deacetylase 2, HD2, RPD3, YAF1, KDAC2, Protein deacylase HDAC2
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Molecular Weight
56.4 kDa (496aa)
Additionnal Information
References & Citations
Betz R. et al. (1998) Genomics. 52:245-6.; ; Taunton J. et al. (1996) Science 272:408-11
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl,1mM DTT, 0.1mM PMSF
Scientific Category
Cell Cycle
NCBI Accession Number
NP_001518.3
Uniprot Accession Number
Q92769
Species
Human
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