Recombinant human Nanog protein
Nanog homeobox, also known as nanog, is a member of the homeobox family of DNA binding transcription factors that has been shown to maintain pluripotency of embryonic stem cells. Nanog expression counteracts the differentiation-promoting signals induced by the extrinsic factors LIF, Stat3 and BMP. Once NANOG expression is downregulated, cell differentiation can proceed. Proteins which regulate NANOG expression include transcription factors Oct4, SOX2, FoxD3, and Tcf3 and tumor suppressor p53.
Product Specifications
Product Name Alternative
Nanog homeobox, hNanog, Homeobox protein NANOG, Homeobox transcription factor Nanog
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
34.6 kDa (305aa)
Additionnal Information
References & Citations
Clark A T., et al. (2004) Stem Cells. 22:169-179.; ; Chambers I., et al. (2003) Cell Res. 13:499-502.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_079141
Uniprot Accession Number
Q9H9S0
Species
Human
AA Sequence
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