Recombinant human DRG1 protein
Developmentally-regulated GTP-binding protein 1 (DRG1) belong to the GTP1/OBG family. It plays a role in cell proliferation and differentiation, as well as in apoptosis, suggesting a role in tumor formation and metastasis. Expression of the DRG1 was significantly reduced in breast tumor cells, particularly in patients with lymph node or bone metastasis as compared to those with localized breast cancer. This protein expressed at high levels in heart, kidney and skeletal muscle and at lower levels in brain, liver, placenta, lung, colon and spleen. Recombinant human DRG1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Developmentally regulated GTP binding protein 1, ADP-ribosylation factor-like 11
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
42.7 kDa (387aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Sazuka, T., et al. (1992) Res. Commun. 189: 363-370.; ; Bandyopadhyay S., et al. (2004) . Oncogene 23 (33) : 5675-81.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 1mM EDTA
Scientific Category
Cancer
NCBI Accession Number
NP_004138
Uniprot Accession Number
Q9Y295
Species
Human
AA Sequence
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
