Recombinant human DRG1 protein

Developmentally-regulated GTP-binding protein 1 (DRG1) belong to the GTP1/OBG family. It plays a role in cell proliferation and differentiation, as well as in apoptosis, suggesting a role in tumor formation and metastasis. Expression of the DRG1 was significantly reduced in breast tumor cells, particularly in patients with lymph node or bone metastasis as compared to those with localized breast cancer. This protein expressed at high levels in heart, kidney and skeletal muscle and at lower levels in brain, liver, placenta, lung, colon and spleen. Recombinant human DRG1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Developmentally regulated GTP binding protein 1, ADP-ribosylation factor-like 11

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

42.7 kDa (387aa) confirmed by MALDI-TOF

Additionnal Information

DRG1, Developmentally regulated GTP binding protein 1, ADP-ribosylation factor-like 11, ATGP1131-10 µg, ATGP1131-20 µg, ATGP1131-50 µg, ATGP1131-100 µg, ATGP1131-250 µg, ATGP1131-500 µg, ATGP1131-1 mg, ATGP1131-10, ATGP1131-20, ATGP1131-50, ATGP1131-100, ATGP1131-250, ATGP1131-500, ATGP1131-1

References & Citations

Sazuka, T., et al. (1992) Res. Commun. 189: 363-370.; ; Bandyopadhyay S., et al. (2004) . Oncogene 23 (33) : 5675-81.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 1mM EDTA

Scientific Category

Cancer

NCBI Accession Number

NP_004138

Uniprot Accession Number

Q9Y295

Species

Human

AA Sequence

MSSTLAKIAE IEAEMARTQK NKATAHHLGL LKARLAKLRR ELITPKGGGG GGPGEGFDVA KTGDARIGFV GFPSVGKSTL LSNLAGVYSE VAAYEFTTLT TVPGVIRYKG AKIQLLDLPG IIEGAKDGKG RGRQVIAVAR TCNLILIVLD VLKPLGHKKI IENELEGFGI RLNSKPPNIG FKKKDKGGIN LTATCPQSEL DAETVKSILA EYKIHNADVT LRSDATADDL IDVVEGNRVY IPCIYVLNKI DQISIEELDI IYKVPHCVPI SAHHRWNFDD LLEKIWDYLK LVRIYTKPKG QLPDYTSPVV LPYSRTTVED FCMKIHKNLI KEFKYALVWG LSVKHNPQKV GKDHTLEDED VIQIVKK